Endocrine Abstracts

All characteristic metabolic properties of a bio-fluid, cell, tissue or an organism are described by its metabolome, which is the functional readout of the genome and proteome. Metabolomics is the newest member in the “omics” cascade investigating the metabolome within a specific biological matrix (e.g. serum, tissue, cells or CSF) offering the possibility of assessing the relationship of a genetic modification to a specific desired phenotype in an effort to determin...

Mass spectrometry based clinical metabolomics needs standardization of analytical assays to improve future inter-laboratory comparability and to become a successful new and established technology in clinical routine laboratories such as mass spectrometry based therapeutic drug monitoring (TDM) over the past 10 years. Steroid hormones are one of the most interesting endogenous metabolite class in clinical metabolomics today. Standardized determination of concentrations of stero...